Patients with poor ovarian response are currently the most challenging group of fertility patients. We are far from understanding the factors which cause reduced ovarian response and further away from finding a solution to this painful problem. A huge variety of definitions for poor ovarian response have been proposed and published in the literature the most widely used being the BOLOGNA  criteria which was proposed in 2011 and which says that at least two of the following criteria should be present to identify a poor responder-1) A previous episode of poor ovarian response  i.e  ≤3 oocyteswith a standard dose of medication (2) An abnormal ovarian reserve with AFC <5–7 follicles or AMH <0.5 –1.1 ng/ml  (3) Women above 40 yearsof age or presenting other riskfactors for poor response such as previous ovarian surgery, genetic defects, chemotherapy, radiotherapy, and autoimmune disorders. Although the Bologna criteria was useful in predicting the outcome of IVF and for counselling, their use in clinical trials has been questioned because it entail the risk of grouping together women who differ significantly in biologic characteristics . Recently to overcome the shortcomings of Bologna criteria the Poseidon Group (Patient-Oriented Strategies Encompassing Individualized Oocyte Number) proposed a change from the definition of POR based on a combination of heterogeneous criteria to a concept of low prognosis. Here the patients are divided into four groups – Group 1: Patients < 35 years with sufficient prestimulation ovarian reserve parameters (AFC>5, AMH >1.2 ng/mL) and with an unexpected poor or suboptimal ovarian response. Group 2: Patients > 35 years with sufficient prestimulation ovarian reserve parameters (AFC>5, AMH >1.2 ng/mL) and with an unexpected poor or suboptimal ovarian response. Group 3: Patients < 35 years with poor ovarian reserve, prestimulation parameters (AFC <5, AMH <1.2 ng/mL). Group 4: Patients >35 years with poor ovarian reserve, prestimulation parameters (AFC <5, AMH <1.2 ng/mL). For a long time Gnrh agonist  long protocol has been a standard protocol but in poor responders standard long protocol causes excessive dampening of the ovarianresponse to COS and complete refractoriness to gonadotropin stimulation. Various modification has been proposed using GnRH agonist like low dose long protocol,Stop protocol,short protocol, ultrashort protocol, microdose  flareup  regimens  all with varying results. We now also have antagonist protocols which has come in a big way and is showing promising results in poor responders. Some modified protocols using antagonist are also in use like delayed-start antagonist  protocol and Crash protocol .Various adjuvants have also been proposed  like r-LH, growth hormones, androgens ,COC  pills ,estrogen, L-arginine and  low dose aspirin. Yet  we are  far  from finding a solution to the problem of poor responders and constant efforts are being made in this direction. Larger and better power studies are needed to find fruitful protocols and interventions to help these group of patients have their biological children and enjoy the joy of parenthood.